First Pregnancy Characteristics, Postmenopausal Breast Density, and Salivary Sex Hormone Levels in a Population at High Risk for Breast Cancer.

ABSTRACT:

Background

It remains unknown if later life breast cancer risk as determined by reproductive history is mediated by postmenopausal breast density and/or sex steroid levels.

Methods

Increased breast density is a strong surrogate for future breast cancer risk. A cross-sectional study with a longitudinal follow up for breast health outcomes evaluated women without breast cancer (n = 1,023; 682 = parous), drawn from a high risk postmenopausal population, with questionnaire reported reproductive histories. The questionnaire was linked to prospective screening mammogram breast density measurements, and saliva biospecimens that were used to assess sex steroid hormone levels.

Results

Expected age and postmenopause related declines in salivary estradiol (E), progesterone (P),

SUBMITTER: Mockus M 

PROVIDER: S-EPMC4547694 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature