MnTBAP stimulates angiogenic functions in endothelial cells through mitofusin-1.

ABSTRACT:

Aims

Angiogenesis is defined as the sprouting of capillaries from pre-existing vasculature. It is a complex process that includes endothelial proliferation, migration, and tube formation. Previous data have demonstrated a high expression level of manganese-superoxide dismutase (MnSOD) in endothelial cells and suggested an important role of MnSOD in several cardiovascular diseases. In addition, manganese (III) tetrakis (4-benzoic acid) porphyrin (MnTBAP) has been shown to mimic some of the effects of MnSOD in various tissues. However, its effect on the vasculature remains unknown.

Methods and results

HUVECs were treated with MnTBAP. Migration, tube formation, and capillary sprouting assays were performed to evaluate the pro-angiogenic effect in vitro. Matrigel plug assay was

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC4547864 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature