The puzzle of processing speed, memory, and executive function impairments in schizophrenia: fitting the pieces together.

ABSTRACT:

Background

Substantial impairment in performance on the digit-symbol substitution task in patients with schizophrenia is well established, which has been widely interpreted as denoting a specific impairment in processing speed. However, other higher order cognitive functions might be more critical to performance on this task. To date, this idea has not been rigorously investigated in patients with schizophrenia.

Methods

Neuropsychological measures of processing speed, memory, and executive functioning were completed by 125 patients with schizophrenia and 272 control subjects. We implemented a series of confirmatory factor and structural regression modeling to build an integrated model of processing speed, memory, and executive function with which to deconstruct the digit-sym

SUBMITTER: Knowles EE 

PROVIDER: S-EPMC4547909 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature