In search of multimodal neuroimaging biomarkers of cognitive deficits in schizophrenia.

ABSTRACT:

Background

The cognitive deficits of schizophrenia are largely resistant to current treatments and thus are a lifelong illness burden. The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) provides a reliable and valid assessment of cognition across major cognitive domains; however, the multimodal brain alterations specifically associated with MCCB in schizophrenia have not been examined.

Methods

The interrelationships between MCCB and the abnormalities seen in three types of neuroimaging-derived maps-fractional amplitude of low-frequency fluctuations (fALFF) from resting-state functional magnetic resonance imaging (MRI), gray matter (GM) density from structural MRI, and fractional anisotropy from diffusion

SUBMITTER: Sui J 

PROVIDER: S-EPMC4547923 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature