Human and Pathogen Factors Associated with Chlamydia trachomatis-Related Infertility in Women.

ABSTRACT: Chlamydia trachomatis is the most common bacterial sexually transmitted pathogen worldwide. Infection can result in serious reproductive pathologies, including pelvic inflammatory disease, ectopic pregnancy, and infertility, in women. However, the processes that result in these reproductive pathologies have not been well defined. Here we review the evidence for the human disease burden of these chlamydial reproductive pathologies. We then review human-based evidence that links Chlamydia with reproductive pathologies in women. We present data supporting the idea that host, immunological, epidemiological, and pathogen factors may all contribute to the development of infertility. Specifically, we review the existing evidence that host and pathogen genotypes, host hormone status, age of sexual

SUBMITTER: Menon S 

PROVIDER: S-EPMC4548260 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature