Polymorphisms of PRLHR and HSPA12A and risk of gastric and colorectal cancer in the Chinese Han population.

ABSTRACT:

Background

Gastric and colorectal cancers have a major impact on public health, and are the most common malignant tumors in China. The aim of this research was to study whether polymorphisms of CHCHD3P1-HSP90AB7P, GRID1, HSPA12A, PRLHR, SBF2, POLD3 and C11orf93-C11orf92 genes are associated with the risk of gastric and colorectal cancers in the Chinese Han population.

Methods

We genotyped seven single nucleotide polymorphisms (SNPs) from seven genes. We selected 588 patients with gastric cancer and 449 with colorectal cancer, along with 703 healthy controls. All these SNPs were evaluated using the χ² test and genetic model analysis.

Results

The genotype "A/T" of rs12413624 in PRLHR gene was associated with a decreased risk of colorectal cancer in allele model analysis

SUBMITTER: Su Q 

PROVIDER: S-EPMC4548694 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature