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Chromatin states and nuclear organization in development--a view from the nuclear lamina.

ABSTRACT: The spatial distribution of chromatin domains in interphase nuclei changes dramatically during development in multicellular organisms. A crucial question is whether nuclear organization is a cause or a result of differentiation. Genetic perturbation of lamina-heterochromatin interactions is helping to reveal the cross-talk between chromatin states and nuclear organization.

SUBMITTER: Mattout A 

PROVIDER: S-EPMC4549078 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Chromatin states and nuclear organization in development--a view from the nuclear lamina.

Mattout Anna A   Cabianca Daphne S DS   Gasser Susan M SM  

Genome biology 20150825

The spatial distribution of chromatin domains in interphase nuclei changes dramatically during development in multicellular organisms. A crucial question is whether nuclear organization is a cause or a result of differentiation. Genetic perturbation of lamina-heterochromatin interactions is helping to reveal the cross-talk between chromatin states and nuclear organization. ...[more]