Subretinal Hyperreflective Material in the Comparison of Age-Related Macular Degeneration Treatments Trials.

ABSTRACT:

Purpose

To evaluate the association of subretinal hyperreflective material (SHRM) with visual acuity (VA), geographic atrophy (GA), and scar in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT).

Design

Prospective cohort study within a randomized clinical trial.

Participants

The 1185 CATT participants.

Methods

Masked readers graded scar and GA on fundus photography and fluorescein angiography and graded SHRM on time-domain and spectral-domain (SD) optical coherence tomography (OCT) throughout 104 weeks. Measurements of SHRM height and width in the fovea, within the center 1 mm(2), or outside the center 1mm(2) were obtained on SD OCT images at 56 (n = 76) and 104 (n = 66) weeks.

Main outcome measures

Presence of SHRM, as well as

SUBMITTER: Willoughby AS 

PROVIDER: S-EPMC4549177 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature