Towards a biomarker panel for the assessment of AKI in children receiving intensive care.

ABSTRACT:

Background

Critically ill children and neonates are at high risk of developing acute kidney injury (AKI). AKI is associated with short- and long-term renal impairment and increased mortality. Current methods of diagnosing AKI rely on measurements of serum creatinine, which is a late and insensitive marker. Few studies to date have assessed AKI biomarkers in a heterogeneous patient cohort.

Methods

We conducted a prospective feasibility study in a paediatric intensive care setting over a 6-month period to describe the relationship between AKI (defined according to pRIFLE criteria) and new AKI biomarkers.

Results

In total, 49 patients between the ages of 16 days and 15 years were recruited for measurement of plasma cystatin C (Cys-C) and neutrophil gelatinase-associated

SUBMITTER: McCaffrey J 

PROVIDER: S-EPMC4549390 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature