Dysglycemia after renal transplantation: Definition, pathogenesis, outcomes and implications for management.

ABSTRACT: New-onset diabetes after transplantation (NODAT) is major complication following renal transplantation. It commonly develops within 3-6 mo post-transplantation. The development of NODAT is associated with significant increase in risk of major cardiovascular events and cardiovascular death. Other dysglycemic states, such as impaired glucose tolerance are also associated with increasing risk of cardiovascular events. The pathogenesis of these dysglycemic states is complex. Older recipient age is a consistent major risk factor and the impact of calcineurin inhibitors and glucocorticoids has been well described. Glucocorticoids likely cause insulin resistance and calcineurin inhibitors likely cause β-cell toxicity. The impact of transplantation in incretin hormones remains to be clarified. The

SUBMITTER: Langsford D 

PROVIDER: S-EPMC4549664 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature