Perspective on the role of Ozurdex (dexamethasone intravitreal implant) in the management of diabetic macular oedema.

ABSTRACT: Diabetic macular oedema (DMO) is the most common cause of visual loss in the working age population. Intravitreal therapy has superseded macular laser as the first-line treatment for the management of centre-involving DMO in most patients. As well as the proven efficacy of intravitreal anti-vascular endothelial growth factor (anti-VEGF) agents, phase II and III clinical trials of Ozurdex intravitreal dexamethasone implants for DMO have also demonstrated a mean increase in visual acuity and corresponding mean reduction in central macular thickness, particularly in pseudophakic eyes. Because of the risk of visual loss from cataract, glaucoma and intraocular infection with the use of intravitreal steroids, Ozurdex tends to be reserved for use in patients unresponsive to anti-VEGF therapy for

SUBMITTER: Mehta H 

PROVIDER: S-EPMC4549694 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature