DRD2 and DRD4 genes related to cognitive deficits in HIV-infected adults who abuse alcohol.

ABSTRACT:

Background

HIV-infected individuals continue to experience neurocognitive deterioration despite virologically successful treatments. The causes of neurocognitive impairment are still unclear. However, several factors have been suggested including the role of genetics. There is evidence suggesting that neurocognitive impairment is heritable and individual differences in cognition are strongly driven by genetic variations. The contribution of genetic variants affecting the metabolism and activity of dopamine may influence these individual differences.

Methods

The present study explored the relationship between two candidate genes (DRD4 and DRD2) and neurocognitive performance in HIV-infected adults. A total of 267 HIV-infected adults were genotyped for polymorphisms, DRD4 48 b

SUBMITTER: Villalba K 

PROVIDER: S-EPMC4549947 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature