DNA methyltransferase DNMT3A associates with viral proteins and impacts HSV-1 infection.

ABSTRACT: Viral infections can alter the cellular epigenetic landscape, through modulation of either DNA methylation profiles or chromatin remodeling enzymes and histone modifications. These changes can act to promote viral replication or host defense. Herpes simplex virus type 1 (HSV-1) is a prominent human pathogen, which relies on interactions with host factors for efficient replication and spread. Nevertheless, the knowledge regarding its modulation of epigenetic factors remains limited. Here, we used fluorescently-labeled viruses in conjunction with immunoaffinity purification and MS to study virus-virus and virus-host protein interactions during HSV-1 infection in primary human fibroblasts. We identified interactions among viral capsid and tegument proteins, detecting phosphorylation of the ca

SUBMITTER: Rowles DL 

PROVIDER: S-EPMC4550099 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature