Baseline Plasma C-Reactive Protein Concentrations and Motor Prognosis in Parkinson Disease.

ABSTRACT:

Background

C-reactive protein (CRP), a blood inflammatory biomarker, is associated with the development of Alzheimer disease. In animal models of Parkinson disease (PD), systemic inflammatory stimuli can promote neuroinflammation and accelerate dopaminergic neurodegeneration. However, the association between long-term systemic inflammations and neurodegeneration has not been assessed in PD patients.

Objective

To investigate the longitudinal effects of baseline CRP concentrations on motor prognosis in PD.

Design, setting, and participants

Retrospective analysis of 375 patients (mean age, 69.3 years; mean PD duration, 6.6 years). Plasma concentrations of high-sensitivity CRP were measured in the absence of infections, and the Unified Parkinson's Disease Rating Scale Par

SUBMITTER: Umemura A 

PROVIDER: S-EPMC4550234 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature