Effects of Long Term Antibiotic Therapy on Human Oral and Fecal Viromes.

ABSTRACT: Viruses are integral members of the human microbiome. Many of the viruses comprising the human virome have been identified as bacteriophage, and little is known about how they respond to perturbations within the human ecosystem. The intimate association of phage with their cellular hosts suggests their communities may change in response to shifts in bacterial community membership. Alterations to human bacterial biota can result in human disease including a reduction in the host's resilience to pathogens. Here we report the ecology of oral and fecal viral communities and their responses to long-term antibiotic therapy in a cohort of human subjects. We found significant differences between the viral communities of each body site with a more heterogeneous fecal virus community compared with v

SUBMITTER: Abeles SR 

PROVIDER: S-EPMC4550281 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature