Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis.

ABSTRACT: Association mapping and candidate gene studies within inflammatory bowel diseases (IBD) linkage regions, as well as genome-wide association studies in Crohn's disease (CD) have led to the discovery of multiple risk genes, but these explain only a fraction of the genetic susceptibility observed in IBD. We have thus been pursuing a region on chromosome 3p21-22 showing linkage to CD and ulcerative colitis (UC) using a gene-centric association mapping approach. We identified 12 functional candidate genes by searching for literature cocitations with relevant keywords and for gene expression patterns consistent with immune/intestinal function. We then performed an association study composed of a screening phase, where tagging single nucleotide polymorphisms (SNPs) were evaluated in 1,020 IBD pat

SUBMITTER: Goyette P 

PROVIDER: S-EPMC4550306 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature