Assessment of Fibrinolysis in Sepsis Patients with Urokinase Modified Thromboelastography.

ABSTRACT:

Introduction

Impairment of fibrinolysis during sepsis is associated with worse outcome. Early identification of this condition could be of interest. The aim of this study was to evaluate whether a modified point-of-care viscoelastic hemostatic assay can detect sepsis-induced impairment of fibrinolysis and to correlate impaired fibrinolysis with morbidity and mortality.

Methods

This single center observational prospective pilot study was performed in an adult Intensive Care Unit (ICU) of a tertiary academic hospital. Forty consecutive patients admitted to the ICU with severe sepsis or septic shock were included. Forty healthy individuals served as controls. We modified conventional kaolin activated thromboelastography (TEG) adding urokinase to improve assessment of fibrinolys

SUBMITTER: Panigada M 

PROVIDER: S-EPMC4550424 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature