Comparison of hematologic measurements between local and central laboratories: data from the BABY HUG trial.

ABSTRACT:

Objectives

To investigate the concordance of blood count indices measured locally and at a central laboratory.

Design and methods

In a multi-center clinical trial of hydroxyurea therapy in infants with sickle cell anemia (BABY HUG), the concordance between blood count indices measured locally and at a central laboratory was investigated.

Results

Local laboratory measurements of neutrophil and monocyte counts were significantly higher (44% and 37%, respectively) compared to the central measurements (p<0.0001), and mean corpuscular volume (MCV) was higher centrally.

Conclusion

Overnight shipping with processing delay causes spurious reductions in absolute neutrophil count (ANC) and absolute monocyte count (AMC) that may result in incorrect monitoring decisions in

SUBMITTER: Kalpatthi R 

PROVIDER: S-EPMC4550480 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature