Associations of Circulating Growth Differentiation Factor-15 and ST2 Concentrations With Subclinical Vascular Brain Injury and Incident Stroke.

ABSTRACT:

Background and purpose

Growth differentiation factor-15 (GDF-15) and soluble (s)ST2 are markers of cardiac and vascular stress. We investigated the associations between circulating concentrations of these biomarkers and incident stroke and subclinical vascular brain injury in a sample from the Framingham Offspring cohort.

Methods

We followed 3374 stroke- and dementia-free individuals (mean age, 59.0±9.7 years; 53% women) attending the Framingham Offspring sixth examination cycle 11.8±3.0 years for incident stroke. A subsample of 2463 individuals underwent brain magnetic resonance imaging and neuropsychological testing ≈4.0±1.7 years after the sixth examination.

Results

After adjustment for traditional cardiovascular risk factors, B-type natriuretic peptide, high-sensi

SUBMITTER: Andersson C 

PROVIDER: S-EPMC4550531 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature