Long-Term Blood-Brain Barrier Permeability Changes in Binswanger Disease.

ABSTRACT:

Background and purpose

The blood-brain barrier (BBB) is disrupted in small vessel disease patients with lacunes and white matter hyperintensities (WMHs). The relationship of WMHs and regional BBB permeability changes has not been studied. We hypothesized that BBB disruption occurs in normal appearing WM and regions near the WMHs. To test the hypothesis, we repeated BBB permeability measurements in patients with extensive WMHs related to Binswanger disease.

Methods

We selected a subset of 22 Binswanger disease subjects from a well-characterized larger prospective vascular cognitive impairment cohort. We used 16 age-matched controls for comparison. The abnormal WM permeability (WMP) was measured twice for several years using dynamic contrast-enhanced magnetic resonance imaging

SUBMITTER: Huisa BN 

PROVIDER: S-EPMC4550546 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature