Adoptive immunotherapy for acute leukemia: New insights in chimeric antigen receptors.

ABSTRACT: Relapses remain a major concern in acute leukemia. It is well known that leukemia stem cells (LSCs) hide in hematopoietic niches and escape to the immune system surveillance through the outgrowth of poorly immunogenic tumor-cell variants and the suppression of the active immune response. Despite the introduction of new reagents and new therapeutic approaches, no treatment strategies have been able to definitively eradicate LSCs. However, recent adoptive immunotherapy in cancer is expected to revolutionize our way to fight against this disease, by redirecting the immune system in order to eliminate relapse issues. Initially described at the onset of the 90's, chimeric antigen receptors (CARs) are recombinant receptors transferred in various T cell subsets, providing specific antigens bindin

SUBMITTER: Heiblig M 

PROVIDER: S-EPMC4550626 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature