A Rich-Club Organization in Brain Ischemia Protein Interaction Network.

ABSTRACT: Ischemic stroke involves multiple pathophysiological mechanisms with complex interactions. Efforts to decipher those mechanisms and understand the evolution of cerebral injury is key for developing successful interventions. In an innovative approach, we use literature mining, natural language processing and systems biology tools to construct, annotate and curate a brain ischemia interactome. The curated interactome includes proteins that are deregulated after cerebral ischemia in human and experimental stroke. Network analysis of the interactome revealed a rich-club organization indicating the presence of a densely interconnected hub structure of prominent contributors to disease pathogenesis. Functional annotation of the interactome uncovered prominent pathways and highlighted the critica

SUBMITTER: Alawieh A 

PROVIDER: S-EPMC4550934 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature