Comparative analysis of protein-protein interactions in cancer-associated genes.

ABSTRACT: Protein-protein interactions (PPIs) have been widely studied to understand the biological processes or molecular functions associated with different disease systems like cancer. While focused studies on individual cancers have generated valuable information, global and comparative analysis of datasets from different cancer types has not been done. In this work, we carried out bioinformatic analysis of PPIs corresponding to differentially expressed genes from microarrays of various tumor tissues (belonging to bladder, colon, kidney and thyroid cancers) and compared their associated biological processes and molecular functions (based on Gene Ontology terms). We identified a set of processes or functions that are common to all these cancers, as well as those that are specific to only one or p

SUBMITTER: Guda P 

PROVIDER: S-EPMC4551074 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature