Functional capacity, health status, and inflammatory biomarker profile in a cohort of patients with chronic obstructive pulmonary disease.

ABSTRACT:

Purpose

Prior research has shown a significant relationship between 6-minute walking distance (6MWD) and health-related quality of life (HRQOL) in patients with chronic obstructive pulmonary disease (COPD). However, few studies have examined this relationship above and below the 350-m threshold that prognosticates survival and whether serum biomarkers could provide insight into the causes of quality-of-life differences above and below this threshold.

Methods

Measures of lung function, 6MWD, and HRQOL were compared in patients with COPD. Differences in HRQOL domains and serum biomarkers were compared in patients whose 6MWD were > or < 350 m.

Results

In patients walking < 350 m, scores in the physical domains of the SF-36 and the St. George's Respiratory Questionnaire (

SUBMITTER: Kohli P 

PROVIDER: S-EPMC4551136 | biostudies-literature | 2015 Sep-Oct

REPOSITORIES: biostudies-literature