Acetylation Regulates Survival of Salmonella enterica Serovar Typhimurium under Acid Stress.

ABSTRACT: The ability to acetylate lysine residues is conserved across organisms, and acetylation of lysine residues plays important roles in various cellular functions. Maintaining intracellular pH homeostasis is crucial for the survival of enteric bacteria in the acidic gastric tract. It has been shown that eukaryotes can stabilize the intracellular pH by histone deacetylation. However, it remains unknown whether bacteria can utilize a reversible protein acetylation system to adapt to an acidic environment. Here we demonstrate that protein acetylation/deacetylation is critical for Salmonella enterica serovar Typhimurium to survive in an acidic environment. We used RNA sequencing to analyze the transcriptome patterns under acid stress and found that the transcriptional levels of genes involved in N

SUBMITTER: Ren J 

PROVIDER: S-EPMC4551269 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature