Ontology highlight
ABSTRACT:
SUBMITTER: Ditadi A
PROVIDER: S-EPMC4551438 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Nature cell biology 20150427 5
The generation of haematopoietic stem cells (HSCs) from human pluripotent stem cells (hPSCs) will depend on the accurate recapitulation of embryonic haematopoiesis. In the early embryo, HSCs develop from the haemogenic endothelium (HE) and are specified in a Notch-dependent manner through a process named endothelial-to-haematopoietic transition (EHT). As HE is associated with arteries, it is assumed that it represents a subpopulation of arterial vascular endothelium (VE). Here we demonstrate at ...[more]