RNAseq analysis of Aspergillus fumigatus in blood reveals a just wait and see resting stage behavior.

ABSTRACT:

Background

Invasive aspergillosis is started after germination of Aspergillus fumigatus conidia that are inhaled by susceptible individuals. Fungal hyphae can grow in the lung through the epithelial tissue and disseminate hematogenously to invade into other organs. Low fungaemia indicates that fungal elements do not reside in the bloodstream for long.

Results

We analyzed whether blood represents a hostile environment to which the physiology of A. fumigatus has to adapt. An in vitro model of A. fumigatus infection was established by incubating mycelium in blood. Our model allowed to discern the changes of the gene expression profile of A. fumigatus at various stages of the infection. The majority of described virulence factors that are connected to pulmonary infections appear

SUBMITTER: Irmer H 

PROVIDER: S-EPMC4551469 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature