Characterization of Virulence-Related Phenotypes in Candida Species of the CUG Clade.

ABSTRACT: Candida species cause a variety of mucosal and invasive infections and are, collectively, the most important human fungal pathogens in the developed world. The majority of these infections result from a few related species within the "CUG clade," so named because they use a nonstandard translation for that codon. Some members of the CUG clade, such as Candida albicans, present significant clinical problems, whereas others, such as Candida (Meyerozyma) guilliermondii, are uncommon in patients. The differences in incidence rates are imperfectly correlated with virulence in animal models of infection, but comparative analyses that might provide an explanation for why some species are effective pathogens and others are not have been rare or incomplete. To better understand the phenotypic basis

SUBMITTER: Priest SJ 

PROVIDER: S-EPMC4551586 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature