Functional Analysis of Sterol Transporter Orthologues in the Filamentous Fungus Aspergillus nidulans.

ABSTRACT: Polarized growth in filamentous fungi needs a continuous supply of proteins and lipids to the growing hyphal tip. One of the important membrane compounds in fungi is ergosterol. At the apical plasma membrane ergosterol accumulations, which are called sterol-rich plasma membrane domains (SRDs). The exact roles and formation mechanism of the SRDs remained unclear, although the importance has been recognized for hyphal growth. Transport of ergosterol to hyphal tips is thought to be important for the organization of the SRDs. Oxysterol binding proteins, which are conserved from yeast to human, are involved in nonvesicular sterol transport. In Saccharomyces cerevisiae seven oxysterol-binding protein homologues (OSH1 to -7) play a role in ergosterol distribution between closely located membranes

SUBMITTER: Buhler N 

PROVIDER: S-EPMC4551590 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature