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Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections.

ABSTRACT: It is widely accepted that D1 dopamine receptor-expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia, whereas D2-expressing neurons do so indirectly via pallidal neurons. Combining optogenetics and electrophysiology, we found that this architecture does not apply to mouse nucleus accumbens projections to the ventral pallidum. Thus, current thinking attributing D1 and D2 selectivity to accumbens projections akin to dorsal striatal pathways needs to be reconsidered.

SUBMITTER: Kupchik YM

PROVIDER: S-EPMC4551610 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections.

Kupchik Yonatan M YM Brown Robyn M RM Heinsbroek Jasper A JA Lobo Mary Kay MK Schwartz Danielle J DJ Kalivas Peter W PW

Nature neuroscience 20150727 9

It is widely accepted that D1 dopamine receptor-expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia, whereas D2-expressing neurons do so indirectly via pallidal neurons. Combining optogenetics and electrophysiology, we found that this architecture does not apply to mouse nucleus accumbens projections to the ventral pallidum. Thus, current thinking attributing D1 and D2 selectivity to accumbens projections akin to dorsal striatal pathways needs ...[more]

PMID: 26214370

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