Changes in beta cell function during the proximate post-diagnosis period in persons with type 1 diabetes.

ABSTRACT:

Objective

Prior studies examining beta-cell preservation in type 1 diabetes have predominantly assessed stimulated C-peptide concentrations approximately 10 wk after diagnosis. We examined whether earlier assessments might aid in prediction of beta cell function over time.

Methods

Using data from a multi-center randomized trial assessing the effect of intensive diabetes management initiated within 1 wk of diagnosis, we assessed which clinical factors predicted 90-min mixed-meal tolerance test (MMTT) stimulated C-peptide values obtained 2 and 6 wk after diagnosis. We also studied associations of these factors with C-peptide values at 1- and 2-year post-diagnosis. Data from intervention and control groups were pooled.

Results

Among 67 study participants (mean age 13.3 ±

SUBMITTER: DiMeglio LA 

PROVIDER: S-EPMC4551616 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature