The effect of caffeine and albuterol on body composition and metabolic rate.

ABSTRACT:

Objective

Caffeine and ephedrine was an effective combination therapy for weight loss until ephedrine was removed from the market due to safety concerns. This study investigated the combination of caffeine and albuterol as a possibly safer alternative to ephedrine.

Methods

In a series of experiments using cultured adipocytes, rat models, and humans, the effects of caffeine and albuterol on lipolysis, metabolic rate, food intake, and body composition were evaluated.

Results

Both caffeine and albuterol enhanced lipolysis in cultured adipocytes. Acute treatment of humans with caffeine and/or albuterol increased resting metabolic rate. Longer-term studies of rats revealed a trend for increased metabolic rate with albuterol treatment. There was increased lean mass gain con

SUBMITTER: Liu AG 

PROVIDER: S-EPMC4551658 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature