Molecular Subsetting of Interferon Pathways in Sjogren's Syndrome.

ABSTRACT:

Objective

Sjögren's syndrome (SS) is an autoimmune disease that targets the salivary and lacrimal glands. While all patients demonstrate inflammatory infiltration and abnormal secretory function in the target tissues, the disease features, pathology, and clinical course can vary. Activation of distinct inflammatory pathways may drive disease heterogeneity. The purpose of this study was to investigate whether activation of the interferon (IFN) pathway correlates with key phenotypic features.

Methods

Clinical data and 1 labial salivary gland (stored frozen) were obtained from each of 82 participants (53 patients with primary SS and 29 control subjects) in the Sjögren's International Collaborative Clinical Alliance (SICCA) registry. Salivary gland lysates were immunoblotted wit

SUBMITTER: Hall JC 

PROVIDER: S-EPMC4551661 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature