Drosophila Hrp48 Is Required for Mushroom Body Axon Growth, Branching and Guidance.

ABSTRACT: RNA binding proteins assemble on mRNAs to control every single step of their life cycle, from nuclear splicing to cytoplasmic localization, stabilization or translation. Consistent with an essential role of RNA binding proteins in neuronal maturation and function, mutations in this class of proteins, in particular in members of the hnRNP family, have been associated with neurological diseases. To date, however, the physiological function of hnRNPs during in vivo neuronal development has remained poorly explored. Here, we have investigated the role of Drosophila Hrp48, a fly homologue of mammalian hnRNP A2/B1, during central nervous system development. Using a combination of mutant conditions, we showed that hrp48 is required for the formation, growth and guidance of axonal branches in Mush

SUBMITTER: Bruckert H 

PROVIDER: S-EPMC4551846 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature