Modular and coordinated expression of immune system regulatory and signaling components in the developing and adult nervous system.

ABSTRACT: During development, the nervous system (NS) is assembled and sculpted through a concerted series of neurodevelopmental events orchestrated by a complex genetic programme. While neural-specific gene expression plays a critical part in this process, in recent years, a number of immune-related signaling and regulatory components have also been shown to play key physiological roles in the developing and adult NS. While the involvement of individual immune-related signaling components in neural functions may reflect their ubiquitous character, it may also reflect a much wider, as yet undescribed, genetic network of immune-related molecules acting as an intrinsic component of the neural-specific regulatory machinery that ultimately shapes the NS. In order to gain insights into the scale and wide

SUBMITTER: Monzon-Sandoval J 

PROVIDER: S-EPMC4551857 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature