EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele.

ABSTRACT: The maintenance of genome stability is critical for the suppression of diverse human pathologies that include developmental disorders, premature aging, infertility and predisposition to cancer. The DNA damage response (DDR) orchestrates the appropriate cellular responses following the detection of lesions to prevent genomic instability. The MRE11 complex is a sensor of DNA double strand breaks (DSBs) and plays key roles in multiple aspects of the DDR, including DNA end resection that is critical for signaling and DNA repair. The MRE11 complex has been shown to function both upstream and in concert with the 5'-3' exonuclease EXO1 in DNA resection, but it remains unclear to what extent EXO1 influences DSB responses independently of the MRE11 complex. Here we examine the genetic relationship

SUBMITTER: Rein K 

PROVIDER: S-EPMC4551929 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature