RefSeq curation and annotation of antizyme and antizyme inhibitor genes in vertebrates.

ABSTRACT: Polyamines are ubiquitous cations that are involved in regulating fundamental cellular processes such as cell growth and proliferation; hence, their intracellular concentration is tightly regulated. Antizyme and antizyme inhibitor have a central role in maintaining cellular polyamine levels. Antizyme is unique in that it is expressed via a novel programmed ribosomal frameshifting mechanism. Conventional computational tools are unable to predict a programmed frameshift, resulting in misannotation of antizyme transcripts and proteins on transcript and genomic sequences. Correct annotation of a programmed frameshifting event requires manual evaluation. Our goal was to provide an accurately curated and annotated Reference Sequence (RefSeq) data set of antizyme transcript and protein records ac

SUBMITTER: Rajput B 

PROVIDER: S-EPMC4551939 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature