Ontology highlight
ABSTRACT:
SUBMITTER: Tapia N
PROVIDER: S-EPMC4551974 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Scientific reports 20150828
The transcription factors OCT4 and SOX2 are required for generating induced pluripotent stem cells (iPSCs) and for maintaining embryonic stem cells (ESCs). OCT4 and SOX2 associate and bind to DNA in different configurations depending on the arrangement of their individual DNA binding elements. Here we have investigated the role of the different OCT4-SOX2-DNA assemblies in regulating and inducing pluripotency. To this end, we have generated SOX2 mutants that interfere with specific OCT4-SOX2 hete ...[more]