Complement Factor C4d Is a Common Denominator in Thrombotic Microangiopathy.

ABSTRACT: Complement activation has a major role in thrombotic microangiopathy (TMA), a disorder that can occur in a variety of clinical conditions. Promising results of recent trials with terminal complement-inhibiting drugs call for biomarkers identifying patients who might benefit from this treatment. The primary aim of this study was to determine the prevalence and localization of complement factor C4d in kidneys of patients with TMA. The secondary aims were to determine which complement pathways lead to C4d deposition and to determine whether complement activation results in deposition of the terminal complement complex. We examined 42 renal sections with histologically confirmed TMA obtained from a heterogeneous patient group. Deposits of C4d, mannose-binding lectin, C1q, IgM, and C5b-9 were s

SUBMITTER: Chua JS 

PROVIDER: S-EPMC4552108 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature