A high-risk study of bipolar disorder. Childhood clinical phenotypes as precursors of major mood disorders.

ABSTRACT:

Context

The childhood precursors of adult bipolar disorder (BP) are still a matter of controversy.

Objective

To report the lifetime prevalence and early clinical predictors of psychiatric disorders in offspring from families of probands with DSM-IV BP compared with offspring of control subjects.

Design

A longitudinal, prospective study of individuals at risk for BP and related disorders. We report initial (cross-sectional and retrospective) diagnostic and clinical characteristics following best-estimate procedures.

Setting

Assessment was performed at 4 university medical centers in the United States between June 1, 2006, and September 30, 2009.

Participants

Offspring aged 12 to 21 years in families with a proband with BP (n = 141, designated as cases) an

SUBMITTER: Nurnberger JI 

PROVIDER: S-EPMC4552246 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature