MGFM: a novel tool for detection of tissue and cell specific marker genes from microarray gene expression data.

ABSTRACT:

Background

Identification of marker genes associated with a specific tissue/cell type is a fundamental challenge in genetic and cell research. Marker genes are of great importance for determining cell identity, and for understanding tissue specific gene function and the molecular mechanisms underlying complex diseases.

Results

We have developed a new bioinformatics tool called MGFM (Marker Gene Finder in Microarray data) to predict marker genes from microarray gene expression data. Marker genes are identified through the grouping of samples of the same type with similar marker gene expression levels. We verified our approach using two microarray data sets from the NCBI's Gene Expression Omnibus public repository encompassing samples for similar sets of five human tissues (br

SUBMITTER: El Amrani K 

PROVIDER: S-EPMC4552366 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature