A comprehensive meta-analysis of common genetic variants in autism spectrum conditions.

ABSTRACT:

Background

Autism spectrum conditions (ASC) are a group of neurodevelopmental conditions characterized by difficulties in social interaction and communication alongside repetitive and stereotyped behaviours. ASC are heritable, and common genetic variants contribute substantial phenotypic variability. More than 600 genes have been implicated in ASC to date. However, a comprehensive investigation of candidate gene association studies in ASC is lacking.

Methods

In this study, we systematically reviewed the literature for association studies for 552 genes associated with ASC. We identified 58 common genetic variants in 27 genes that have been investigated in three or more independent cohorts and conducted a meta-analysis for 55 of these variants. We investigated publication bias

SUBMITTER: Warrier V 

PROVIDER: S-EPMC4552442 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature