MRI measurement of blood-brain barrier transport with a rapid acquisition refocused echo (RARE) method.

ABSTRACT: Dynamic Contrast Enhanced (DCE) MRI is increasingly being used to assess changes in capillary permeability. Most quantitative techniques used to measure capillary permeability are based on the Fick equation that requires measurement of signal reflecting both plasma and tissue concentrations of the solute being tested. To date, most Magnetic Resonance Imaging (MRI) methods for acquiring appropriate data quickly rely on gradient recalled echo (GRE) type acquisitions, which work well in clinical low field settings. However, acquiring this type of data on high field small animal preclinical MRIs is problematic due to geometrical distortions from susceptibility mismatch. This problem can be exacerbated when using small animal models to measure blood brain barrier (BBB) permeability, where preci

SUBMITTER: Walton JH 

PROVIDER: S-EPMC4552450 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature