Genome-Wide Study of Structural Variants in Bovine Holstein, Montbeliarde and Normande Dairy Breeds.

ABSTRACT: High-throughput sequencing technologies have offered in recent years new opportunities to study genome variations. These studies have mostly focused on single nucleotide polymorphisms, small insertions or deletions and on copy number variants. Other structural variants, such as large insertions or deletions, tandem duplications, translocations, and inversions are less well-studied, despite that some have an important impact on phenotypes. In the present study, we performed a large-scale survey of structural variants in cattle. We report the identification of 6,426 putative structural variants in cattle extracted from whole-genome sequence data of 62 bulls representing the three major French dairy breeds. These genomic variants affect DNA segments greater than 50 base pairs and correspond t

SUBMITTER: Boussaha M 

PROVIDER: S-EPMC4552564 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature