Array CGH Analysis of Paired Blood and Tumor Samples from Patients with Sporadic Wilms Tumor.

ABSTRACT: Wilms tumor (WT), the most common cancer of the kidney in infants and children, has a complex etiology that is still poorly understood. Identification of genomic copy number variants (CNV) in tumor genomes provides a better understanding of cancer development which may be useful for diagnosis and therapeutic targets. In paired blood and tumor DNA samples from 14 patients with sporadic WT, analyzed by aCGH, 22% of chromosome abnormalities were novel. All constitutional alterations identified in blood were segmental (in 28.6% of patients) and were also present in the paired tumor samples. Two segmental gains (2p21 and 20q13.3) and one loss (19q13.31) present in blood had not been previously described in WT. We also describe, for the first time, a small, constitutive partial gain of 3p22.1 co

SUBMITTER: Cabral de Almeida Cardoso L 

PROVIDER: S-EPMC4552764 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature