Thalamocortical relationship in epileptic patients with generalized spike and wave discharges--A multimodal neuroimaging study.

ABSTRACT: Unlike focal or partial epilepsy, which has a confined range of influence, idiopathic generalized epilepsy (IGE) often affects the whole or a larger portion of the brain without obvious, known cause. It is important to understand the underlying network which generates epileptic activity and through which epileptic activity propagates. The aim of the present study was to investigate the thalamocortical relationship using non-invasive imaging modalities in a group of IGE patients. We specifically investigated the roles of the mediodorsal nuclei in the thalami and the medial frontal cortex in generating and spreading IGE activities. We hypothesized that the connectivity between these two structures is key in understanding the generation and propagation of epileptic activity in brains affected

SUBMITTER: Zhang CH 

PROVIDER: S-EPMC4552814 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature