Cerebral amyloidosis associated with cognitive decline in autosomal dominant Alzheimer disease.

ABSTRACT:

Objective

To investigate the associations of cerebral amyloidosis with concurrent cognitive performance and with longitudinal cognitive decline in asymptomatic and symptomatic stages of autosomal dominant Alzheimer disease (ADAD).

Methods

Two hundred sixty-three participants enrolled in the Dominantly Inherited Alzheimer Network observational study underwent neuropsychological evaluation as well as PET scans with Pittsburgh compound B. One hundred twenty-one participants completed at least 1 follow-up neuropsychological evaluation. Four composite cognitive measures representing global cognition, episodic memory, language, and working memory were generated using z scores from a battery of 13 standard neuropsychological tests. General linear mixed-effects models were used to i

SUBMITTER: Wang F 

PROVIDER: S-EPMC4553024 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature