Response to endovascular reperfusion is not time-dependent in patients with salvageable tissue.

ABSTRACT:

Objective

To evaluate whether time to treatment modifies the effect of endovascular reperfusion in stroke patients with evidence of salvageable tissue on MRI.

Methods

Patients from the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution 2 (DEFUSE 2) cohort study with a perfusion-diffusion target mismatch were included. Reperfusion was defined as a decrease in the perfusion lesion volume of at least 50% between baseline and early follow-up. Good functional outcome was defined as a modified Rankin Scale score ≤2 at day 90. Lesion growth was defined as the difference between the baseline and the early follow-up diffusion-weighted imaging lesion volumes.

Results

Among 78 patients with the target mismatch profile (mean age 66 ± 16 years, 54% women

SUBMITTER: Lansberg MG 

PROVIDER: S-EPMC4553034 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature