Safety and efficacy of digoxin: systematic review and meta-analysis of observational and controlled trial data.

ABSTRACT:

Objective

To clarify the impact of digoxin on death and clinical outcomes across all observational and randomised controlled trials, accounting for study designs and methods.

Data sources and study selection

Comprehensive literature search of Medline, Embase, the Cochrane Library, reference lists, and ongoing studies according to a prospectively registered design (

Prospero

CRD42014010783), including all studies published from 1960 to July 2014 that examined treatment with digoxin compared with control (placebo or no treatment).

Data extraction and synthesis

Unadjusted and adjusted data pooled according to study design, analysis method, and risk of bias.

Main outcome measures

Primary outcome (all cause mortality) and secondary outcomes (including admissi

SUBMITTER: Ziff OJ 

PROVIDER: S-EPMC4553205 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature