Physical function impairment of older, HIV-infected adults is associated with cytomegalovirus immunoglobulin response.

ABSTRACT: Cytomegalovirus (CMV) is associated with poor outcomes, including physical function impairment, in older HIV-uninfected adults. Whether CMV is associated with physical functional impairment in HIV-infected adults is unknown. The primary objective of this study was to determine the relationship between CMV-specific humoral and cell-mediated immune responses with functional impairment in well-controlled HIV infection. In a case-control study, low-function cases were matched by age, gender, and time from HIV diagnosis to high-function controls. Quantitative CMV IgG and %CMV-specific CD8(+) and CD4(+) T cells (interferon-γ expression following CMV pp65 stimulation) were used to estimate physical function. Among 30 low-function cases and 48 high-function matched controls, CMV IgG ranged from <1

SUBMITTER: Erlandson KM 

PROVIDER: S-EPMC4553372 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature